4-Androstenedione CAS No:63-05-8

Product Description

Product Name:4-Androstenedione

CAS No:63-05-8

M.F:C19H26O2

M.W:286.41

Appearance:White crystalline powder

Uses:It is widely used in small rheumatoid arthritis, diuretic, and a variety of contraceptive to control infectious inflammation.

Description:

Function:

4- Androstenedione can be used as pharmaceutical material, steroid hormone and anabolin.

4- Androstenedione can be used for treatment of anorchia replacement therapy.

4- Androstenedione can be used to increase the number of muscle.

4-Androstenedione Application:

4-Androstenedione is the common precursor of male and female sex hormones. Some 4-Androstenedione is also secreted into the plasma, and may be converted in peripheral tissues to testosterone and estrogens.

4-Androstenedione can be synthesized in one of two ways. The primary pathway involves conversion of 17-hydroxypregnenolone to dehydroepiandrosterone by way of 17,20-lyase, with subsequent conversion of dehydroepiandrosterone to 4-Androstenedione via the enzyme 3-hydroxysteroid dehydrogenase. The secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to 4-androstenedione directly by way of 17,20-lyase. Thus, 17,20-lyase is required for the synthesis of 4-androstenedione, whether immediately or one step removed.

The production of adrenal 4-Androstenedione is governed by ACTH, whereas production of gonadal 4-Androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and ovaries each produce about half of the total 4-androstenedione(about 3 mg/day). After menopause, 4-androstenedione production is about halved, due primarily to the reduction of the steroid secreted by the ovary. Nevertheless, 4-androstenedione is the principal steroid produced by the postmenopausal ovary.